Objective: To describe the primary carcinoma of the retroperitoneum that was positive\nfor human papillomavirus (HPV), a surrogate molecular marker for high-risk\nHPV (p16) and p53. Methods: This is a case report. Results: We report a case of 50-\nyear-old woman with a large retroperitoneal mass (squamous cell carcinoma on histology)\nthat was treated in September of 2014 with radical concurrent chemotherapy\nwith weekly cisplatin and pelvic radiation (4500 cGY) and additional right pelvic\nboost of 900 cGY. It was assumed she had FIGO stage IIIB local advanced cervical\ncancer. She initially presented with the right leg swelling, severe pain and difficulty in\nwalking and was treated with antibiotics for presumed cellulitis. Several months later\nright leg extensive deep vein thrombosis (DVT) was diagnosed and was started on\nanticoagulation. CT scan and MRI reported a large right-sided retroperitoneal mass\noccluding the illiac vessels and ureter. The mass had invaded into the adjacent pelvic\nsidewall, with destruction of the iliacus muscle and underlying iliac wing. MRI\nshowed that the cervix and uterus were both normal. On examination cervix appeared\ngrossly normal and cervical punch biopsy revealed HSIL only. CT-guided biopsy\nof the mass revealed a moderately differentiated squamous cell carcinoma positive\nfor p16 and p53. Conclusion: Primary squamous cell carcinoma of the retroperitoneum\nis a real entity that is unknown. It is unclear if primary neoplasia in the cervix\nwas small from which a cell clone arose and migrated to the retroperitoneal\nspace.
Loading....